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Related Experiment Video

Updated: Nov 6, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Post-mortem persistence of SARS-CoV-2: a preliminary study.

Sara Sablone1, Biagio Solarino2, Davide Ferorelli1

  • 1Section of Legal Medicine, Department of Interdisciplinary Medicine, Bari Policlinico Hospital, University of Bari, 70124, Bari, Italy.

Forensic Science, Medicine, and Pathology
|May 8, 2021
PubMed
Summary
This summary is machine-generated.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can persist in cadaver tissues for days after death, even under extreme preservation conditions. This finding impacts forensic pathology and autopsy safety protocols for coronavirus disease 19 (Covid-19).

Keywords:
COVID-19 autopsyCadaver tissue samplesPost-mortem intervalSARS-CoV-2Viral RNA

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Area of Science:

  • Forensic Pathology
  • Infectious Diseases
  • Virology

Background:

  • The global COVID-19 pandemic necessitates understanding SARS-CoV-2 in post-mortem settings.
  • Forensic pathology and autopsy practices are crucial for accurate death record-keeping.
  • Limited data exists on SARS-CoV-2 persistence in cadavers and its implications.

Purpose of the Study:

  • To investigate the survival of SARS-CoV-2 in various cadaver tissues.
  • To assess the duration of viral RNA detection in post-mortem samples.
  • To inform safety protocols for pathologists handling deceased COVID-19 cases.

Main Methods:

  • Analysis of SARS-CoV-2 RNA in multiple tissues from deceased individuals.
  • Evaluation of viral persistence under varying post-mortem preservation conditions.
  • Preliminary observational study of cadaveric samples.

Main Results:

  • SARS-CoV-2 was found to survive in multiple cadaver tissues.
  • Viral persistence was observed for many days post-mortem.
  • Survival occurred despite extreme post-mortem body preservation conditions.

Conclusions:

  • SARS-CoV-2 can remain viable in cadaver tissues long after death.
  • Findings emphasize the need for enhanced safety measures in forensic autopsies.
  • Further research is needed on virus--tissue interactions and supravital reactions.