[TELOMERASE ACTIVITY AS A POTENTIAL BIOMARKER FOR PREOPERATIVE DIFFERENTIAL DIAGNOSIS OF CYSTIC NEOPLASMS OF THE...

The goal of the study was to find ways to improve the quality of preoperative diagnosis of mucinous cystic liver neoplasms using such tumor markers as CA 19-9 and telomerase activity. We conducted a retrospective analysis and a prospective study that included the results of treatment of 80 patients with cystic neoplasm of the liver (31 with MCNL, 36 with multichamber non-parasitic cysts (NPC), 13 with stage II (WHO classification) echinococcus liver cysts. Our study showed the presence of telomerase activity in 29 (93.5%) patents with MCNL (in case of IMCNL, the TA was high both in the tumor itself and the CNL content).16 patients demonstrated high TA (+++) both in the tumor itself and the CNL content; 11 and 2 patients had moderate (++) and low (+) TA, respectively. 12 (38.7%) patients with MCNL had the CA 19-9 level above 1000 U/L, 14 (45.1%) - above 10,000 U/L, and 3 (9.6%) - above 100,000 U/L, while only 1 (6.5%) patient had the CA 19-9 level <1000 U/L. The analysis of data showed the absence of TA in the CNL content in 33 of 36 patients with NPC. However, three patients demonstrated a low activity of telomerase. CA 19-9 levels were below 1000 U/L in 27 (75%) of 36 patients with NPC. It was established that the determination of TA and the level CA 19-9 in the contents of the CNL is a valuable method, which makes it possible to carry out a preoperative differential diagnosis of CNL with a high probability.