CLINICAL, PHARMACOTHERAPEUTIC AND BIORHYTHMOLOGICAL PECULIARITIES OF DEPRESSIVE DISORDERS, COMORBID WITH
K Hryn1, A Sydorenko2, O Vlasova2
11Ukrainian Medical Stomatological Academy, Department of Experimental and Clinical Pharmacology, Сlinical Іmmunology and Аllergology, Poltava; 2Communal Еnterprise «Regional Institution for Providing Psychiatric Care of Poltava Regional Council», Ukraine.
Insights
Depressive disorders significantly impact cardiovascular health. Chronotherapy, integrating antihypertensive and antidepressant treatments, demonstrated superior patient improvement compared to standard care in patients with comorbid cardiac conditions.
Area of Science:
- Psychiatry
- Cardiology
- Pharmacology
Background:
- Depressive disorders are prevalent and exacerbate cardiovascular conditions.
- Comorbid depression negatively affects patient prognosis and adaptive capacity.
- Effective therapy is crucial for managing depression and preventing adverse outcomes.
Purpose of the Study:
- To investigate clinical, pharmacotherapeutic, and biorhythmic features of depression in cardiac patients.
- To assess the efficacy of complex therapy incorporating chronotherapy principles.
Main Methods:
- Study included 50 female patients with depressive disorders and comorbid arterial hypertension.
- Utilized clinical, laboratory, and psychopathological assessments with scales like HAMD-21, CGI-S, and CGI-I.
- Individual biorhythmic status was determined and considered for treatment.
Main Results:
- Chronotherapy, particularly combined antihypertensive and antidepressant treatment, showed better patient improvement dynamics.
- Patients receiving chronotherapy exhibited more favorable outcomes than those in the control group.
- Biorhythmic status influenced therapeutic strategies and outcomes.
Conclusions:
- Complex therapy based on chronotherapy principles is effective for depressive disorders with comorbid cardiac pathology.
- Timing of antihypertensive and antidepressant medication is critical for optimizing treatment outcomes.
- Addressing biorhythmic patterns is essential for personalized depression management in cardiac patients.
Abstract:
The spread of depressive disorders is extra high nowadays. Depressive disorders are widespread mental disorders in the structure of mental pathology, both causes of psychiatrists' visit, and causes of medical aid. The presence of depressive syndrome in patients with cardiovascular system leads to deterioration patient's condition and adaptive abilities and aggravates somatic abnormality. Adequate therapy causes their reduction, prevention of recurrence and decompansation of comorbid somatic pathology, and eliminates severe medical and prevents social consequences. The study of clinical aspects of depressive conditions which are accompanied with pathology is one of the direction not only psychiatric, but also common pharmacotherapeutic investigations. The aim of the investigation was to determine clinical, pharmacotherapeutic and biorhythmic peculiarities of depressive disorders in patients with comorbid cardiac pathology. And also assessment of efficacy of complex therapy based on chronotherapy principle was used. 50 patients (female patients) with depressive disorders were involved in this investigation. This was performed based on "Depressive disorders of organic genesis, characterized by somatic pathology" (F 06.35), "Somatoform disorder" of heart and cardiovascular system (F 45.30), "Mild depressive episode" (F 32.00), and also comorbid arterial hypertension confirmed by physician. Clinical, laboratory, clinical and psychopathological investigations using psychodiagnostic scales (scale HAMD-21, CGI-S, CGI-І) were used. Individual biorhythmic status was established and it requires medicamentous therapy. Comparing patients of both groups, it has been detected a group of patients in whom principles of chronotherapy, especially antihypertensive and antidepressive therapy were prescribed, dynamics of patient's improvement was better than in the investigated group where the principle of chronotherapy was observed.
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