HEPATOPROTECTIVE EFFICIENCY OF G10 SUBSTANCE FROM ZHUZGUN PLANT IN EXPERIMENTAL TOXIC HEPATITIS

The article presents the results of biochemical studies of blood and morphological characteristics of liver changes in laboratory animals (rats) under experimental conditions of paracetamol hepatitis and intragastric administration of a new substance G10 from the «Zhuzgun» plant in various doses. The obtained data open up prospects for further studies of the pharmacological properties of the substance G10, the possibility of including it as a phytotherapeutic agent in the complex of preventive and therapeutic measures for acute toxic hepatitis. The study of the hepatoprotective properties was conducted in the "Educational and Research Pharmacological Laboratory" of the Department of General Pharmacology of the Astana Medical University. The object of the study was the substance G. 10 from the Juzgun plant, which is a brown powder, odorless, poorly soluble in water. Тhe analysis of the results of our own research allows us to conclude that the substance G10 obtained from the plant «Zhuzgun» in various doses has a significant positive effect on the dynamics of biochemical parameters of blood serum in animals with experimental acute paracetamol hepatitis.The results of pathomorphological examination of the internal organs of laboratory animals (rats) with intragastric administration of substance G10 also allow us to conclude that it has a hepatoprotective effect. The results of microscopic and biochemical studies of laboratory animals (rats) in acute toxic hepatitis with a new substance from the plant Calligonum allow us to conclude that the substance G10 has a hepatoprotective property. The obtained preliminary data on the hepatoprotective efficacy of substance G10 open up new prospects for further studies of its pharmacological properties.