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Updated: Nov 6, 2025

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

Silver nanoparticles are effective in controlling microsporidia.

Zhanqi Dong¹, Qin Wu², Jiangqiong Long²

¹State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China; Key Laboratory of Sericultural Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, Southwest University, Chongqing 400716, China.

Materials Science & Engineering. C, Materials for Biological Applications

|May 9, 2021

Summary

Silver nanoparticles (AgNPs) show promise in combating microsporidian infections by disrupting spore membranes and inhibiting germination. This research suggests AgNPs could be key components in novel therapeutic formulations against microsporidia.

Keywords:

AgNPs Antimicrobial activities Biomaterial Bombyx mori Microsporidia

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Area of Science:

Nanotechnology
Microbiology
Parasitology

Background:

Microsporidian infections pose a significant challenge due to the lack of effective, broad-spectrum treatments.
Silver nanoparticles (AgNPs) exhibit broad-spectrum antimicrobial properties, offering a potential avenue for novel therapeutic development.

Purpose of the Study:

To synthesize and characterize silver nanoparticles (AgNPs).
To evaluate the efficacy of AgNPs against the microsporidian Nosema bombycis.
To explore AgNPs as a potential therapeutic agent for microsporidiosis.

Main Methods:

AgNPs were synthesized using a chemical reduction method.
Characterization of AgNPs involved transmission electron microscopy (TEM) and ultraviolet spectroscopy.
Anti-microsporidian activity was assessed by observing effects on spore viability, germination, and silkworm larvae survival rates.

Main Results:

Synthesized AgNPs demonstrated disruption of the Nosema bombycis spore cell membrane and inhibited spore germination.
AgNPs induced the release of essential microsporidian components, including nucleic acids, proteins, and respiratory enzymes.
Treatment with AgNPs significantly improved silkworm larvae survival rates and reduced spore genome replication post-infection.

Conclusions:

Silver nanoparticles possess significant anti-microsporidian activity against Nosema bombycis.
AgNPs are effective in damaging microsporidian spores and preventing their proliferation.
AgNPs represent a promising component for developing new formulations to treat or prevent microsporidian infections.