Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Biological Effects of Radiation

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multicentered Biospecimen Analyses after 4 Gy Sublethal Total Body Irradiation in Rhesus Macaques.

Radiation research·2025

Same author

Development of Nanocarrier-Based Oral Pegfilgrastim Formulations for Mitigating Hematopoietic Acute Radiation Syndrome.

Advanced functional materials·2025

Same author

Anti-Tumor Immunization Efficacy after Particle-Radiation Exposure.

Radiation research·2025

Same author

Centers for Medical Countermeasures against Radiation Consortium: Past, Present, and Beyond.

Radiation research·2025

Same author

Sex Differences in Urinary Metabolite Profiles between Survivors and Non-Survivors of Radiation-induced Lung Injury in the C57L/J Murine Model.

Radiation research·2025

Same author

Maintaining competence in radiation protection research: a position statement by the MELODI scientific advisory committee.

Radiation and environmental biophysics·2025

Search research articles

Related Experiment Video

Updated: Nov 6, 2025

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Published on: February 20, 2021

Transcriptomics for radiation biodosimetry: progress and challenges.

Sally A Amundson¹

¹Center for Radiological Research, Columbia University Irving Medical Center, New York, NY, USA.

International Journal of Radiation Biology

|May 10, 2021

Summary

This summary is machine-generated.

Transcriptomic approaches offer a promising method for radiation dose assessment and injury prediction after radiological events. Further research is needed to ensure the reliability of gene expression signatures for emergency biodosimetry.

Keywords:

Ionizing radiation biodosimetry dose reconstruction gene expression radiological triage

More Related Videos

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Related Experiment Videos

Last Updated: Nov 6, 2025

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Published on: February 20, 2021

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Area of Science:

Radiation biology
Genomics
Biomedical science

Background:

Current biodosimetry methods face limitations in large-scale assessments.
Radiological or nuclear events necessitate rapid and accurate dose estimation for population triage.
Transcriptomic analysis offers a novel approach for radiation injury assessment.

Approach:

This review summarizes advances in transcriptomic-based biodosimetry.
It discusses model systems used for developing gene expression signatures.
The review examines challenges in applying these signatures to real-world scenarios.

Key Points:

Transcriptomic approaches can aid in dose reconstruction and injury prediction.
Gene expression signatures are being developed for radiation exposure assessment.
Individual variation and confounding factors pose challenges to signature robustness.

Conclusions:

Transcriptomic biodosimetry shows significant promise for radiological emergencies.
Further development is required to ensure gene expression signatures are robust and suitable for practical use.
Reliable gene expression signatures are crucial for effective radiation dose assessment and triage.