Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Lipidomics of longer-term effects in the murine model after exposure to mixed field radiation and combined infection.

Metabolomics : Official journal of the Metabolomic Society·2026

Same authorSame journal

Characterization of Radiation-responsive Genes and Transcript Variants under Different Radiation Qualities, Doses and Dose Rates.

Radiation research·2026

Same author

The Effects of Intraocular Pressure-Lowering Drops on the Tear Film Assessed by a Novel High-Resolution Tear Film Imager.

Diagnostics (Basel, Switzerland)·2026

Same author

Estimating temporal treatment-effect patterns of radiotherapy and chemotherapy in lower-grade gliomas using causal machine learning.

Scientific reports·2026

Same author

Further insights on the antimicrobial effectiveness of far-UVC light.

Photochemistry and photobiology·2026

Same author

Depth of DNA photodamage in human corneas exposed to 222 nm or 254 nm UV.

Photochemistry and photobiology·2026

Same journal

KRT6A Impairs Radiosensitivity in Cervical Squamous Cell Carcinoma by Enhancing Fatty Acid Synthesis.

Radiation research·2026

Same journal

Chromosomal Instability: A Potential Biomarker of Radiation Response.

Radiation research·2026

Same journal

Antioxidant Probucol Reduces Mortality in Mice Exposed to Lethal Doses of Ionizing Radiation.

Radiation research·2026

Same journal

The Detection of Radiation Effects in the Urine of Rhesus Macaques Using Raman Spectroscopy.

Radiation research·2026

Same journal

Methyl Quercetin Inhibits Radiation-induced Senescence and TGF-β1-induced Myofibroblast Differentiation Through Psmad3/TGF-Β Signaling.

Radiation research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 17, 2025

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

Anti-Tumor Immunization Efficacy after Particle-Radiation Exposure.

Brian Ponnaiya¹, Naresh T Deoli¹, Guy Garty¹

¹Center for Radiological Research, Columbia University Irving Medical Center, New York, New York.

Radiation Research

|June 30, 2025

Summary

This summary is machine-generated.

High-energy particle radiotherapy, particularly heavy ions, shows greater potential than X-rays in stimulating systemic anti-cancer immune responses. This finding may explain the effectiveness of particle therapy against resistant cancers.

More Related Videos

Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells

Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells

Published on: May 17, 2019

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

Related Experiment Videos

Last Updated: Sep 17, 2025

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells

Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells

Published on: May 17, 2019

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

Area of Science:

Oncology
Radiation Oncology
Immunology

Background:

Particle radiotherapy is effective against radioresistant cancers, but mechanisms are unclear.
Systemic immune effects of particle radiotherapy are hypothesized but not well understood.
Conventional low-linear energy transfer (low-LET) therapy efficacy is limited for certain tumors.

Purpose of the Study:

To compare the in vivo anti-tumor immune response induced by particle radiotherapy versus X-rays.
To investigate the potential of particle radiotherapy to generate systemic anti-cancer effects.
To elucidate the mechanisms behind the success of particle radiotherapy in treating refractory cancers.

Main Methods:

Utilized a previously established immunization model in mice.
Assessed in vivo anti-tumor responses.
Compared tumor cell killing efficacy of X-rays and high-linear energy transfer (high-LET) ions at equidoses.

Main Results:

Heavy ion radiotherapy was more effective than X-rays in generating anti-tumor responses at equidoses.
Particle radiotherapy demonstrated a superior ability to induce protective anti-tumor immunity.
The study provides evidence for systemic effects mediated by particle radiotherapy.

Conclusions:

Heavy ions are more effective than X-rays in eliciting anti-tumor immune responses.
Particle radiotherapy may leverage systemic immunity for enhanced anti-cancer effects.
Further research into the immunological mechanisms of particle radiotherapy is warranted.