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The Physiologic Response to COVID-19 Vaccination.
Medrxiv : the Preprint Server for Health Sciences
|May 11, 2021
Summary
Resting heart rate changes after COVID-19 vaccination were tracked using smartwatch data. Elevated heart rates peaked two days post-vaccination, offering insights into vaccine response.
Area of Science:
- Immunology
- Digital Health
- Cardiology
Background:
- Physiologic responses to SARS-CoV-2 vaccines are not routinely monitored.
- Understanding individual immune responses can inform vaccine effectiveness and characteristics.
Approach:
- Utilized a smartphone app research platform with 3,312 participants reporting smartwatch data.
- Analyzed resting heart rate (RHR) changes around mRNA vaccination dates (March 2020 - April 2021).
Key Points:
- RHR increased post-vaccination, peaking on day 2 and normalizing by day 6.
- Second mRNA vaccine doses showed a stronger RHR effect than first doses.
- Moderna vaccine recipients, those with prior COVID-19, and individuals <40 years exhibited more pronounced RHR changes.
Conclusions:
- Continuous passive sensor data may provide a 'digital fingerprint' of inflammation.
- This digital biomarker could serve as a surrogate for vaccine-induced immune responses.
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