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Related Experiment Video

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MRI-Compatible and Conformal Electrocorticography Grids for Translational Research.

Florian Fallegger1, Giuseppe Schiavone1, Elvira Pirondini2,3

  • 1Bertarelli Foundation Chair in Neuroprosthetic Technology Laboratory for Soft Bioelectronic Interfaces Institute of Microengineering Institute of Bioengineering Center for Neuroprosthetics Ecole Polytechnique Fédérale de Lausanne (EPFL) Geneva 1202 Switzerland.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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Summary

New soft electrocorticography (ECoG) grids offer improved conformability for brain surface access. These flexible grids demonstrate safe MRI compatibility and effective neural recording, paving the way for advanced epilepsy and tumor surgeries.

Keywords:
MRI compatibilityelectrocorticographyneural implantssoft electrodestranslational research

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Current electrocorticography (ECoG) grids are rigid, limiting surgical access and spatial resolution.
  • Existing ECoG technology faces challenges in conforming to complex brain surfaces, hindering comprehensive neural data acquisition.

Purpose of the Study:

  • To develop and evaluate novel conformable, thin-film ECoG grids using soft neurotechnology.
  • To assess the suitability of these soft ECoG grids for translational research and clinical applications.

Main Methods:

  • Manufactured soft ECoG grids with varying electrode pitches (0.2–10 mm) embedded in thin silicone membranes.
  • Evaluated grid conformability in human cadaveric models, including interfacing with the Sylvian fold.
  • Assessed MRI compatibility (3T scanner) for imaging artifacts and local heating.
  • Validated subdural neural activity recording in minipigs acutely and post-implantation (2 weeks).

Main Results:

  • Soft grids demonstrated safe folding and interfacing with complex cerebral surfaces.
  • Thin-film conductors produced minimal imaging artifacts (<1 mm) and no adverse local heating during MRI.
  • Successful recording of subdural neural activity in minipigs was achieved both acutely and chronically.

Conclusions:

  • The developed soft ECoG grids represent a promising alternative to current rigid electrodes.
  • These conformable grids may enhance surgical interventions for epilepsy and tumors.
  • The findings support the potential adoption of soft ECoG grids in translational research and clinical settings.