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Related Concept Videos

Necrosis01:16

Necrosis

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
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Related Experiment Video

Updated: Nov 5, 2025

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
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Massive necrotizing Fournier's gangrene.

Fernando Rivera-Alvarez1, Andrew George2, Latha Ganti1,3

  • 1HCA Healthcare University of Central Florida Graduate Medical Consortium Emergency Medicine Residency Program of Greater Orlando Author Contributions, USA.

Urology Case Reports
|May 17, 2021
PubMed
Summary

Fournier's gangrene is a rare but deadly necrotizing infection. Prompt diagnosis and surgical intervention, including debridement and grafting, are vital for patient survival, especially in those with comorbidities.

Keywords:
Fournier's gangreneNecrotizing infections

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Area of Science:

  • Urology
  • Infectious Diseases
  • Dermatology

Background:

  • Fournier's gangrene is a severe, rapidly progressing necrotizing infection of the genitalia and perineum.
  • Early recognition and aggressive management are crucial for improving patient outcomes and reducing mortality.

Observation:

  • A case of Fournier's gangrene in an elderly male with poorly controlled diabetes mellitus and hypertension is presented.
  • Imaging studies, including ultrasound and CT, revealed extensive scrotal and perineal involvement.

Findings:

  • The patient required surgical intervention, including scrotectomy and partial colostomy.
  • Extensive debridement and subsequent skin grafting were necessary due to the widespread necrotizing infection.

Implications:

  • This case highlights the importance of a high index of suspicion for Fournier's gangrene in at-risk populations.
  • Multidisciplinary management involving urology, surgery, and infectious disease specialists is essential for successful treatment.
  • Prompt surgical debridement and reconstruction are key components of managing this devastating condition.