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Hepatitis B and C among patients with hidradenitis suppurativa: a population-based study
Jeffrey M Cohen1, Khalaf Kridin2, Lourdes M Perez-Chada3
1Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.
Background:
Hidradenitis suppurativa (HS) is a chronic inflammatory condition related to multiple systemic diseases and infections.
Methods:
This retrospective cross-sectional study from 1999 to 2015 used the database of Clalit Health Services, the largest managed care organization in Israel, to explore the association between HS and hepatitis B and C. Sociodemographic and clinical information was compared using χ2 tests for sex and socioeconomic status and t-tests for age. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to compare the odds of hepatitis B and C in those with and without HS.
Results:
In multivariate analysis controlling for sex, age as a continuous variable, Arab ancestry, and history of drug abuse, HS was associated with a 1.87-fold increased odds (95% CI 1.11-3.17, P = 0.019) of hepatitis B (HBV). HS was also associated with HCV in multivariate analysis controlling for sex, age per year, Arab ancestry, alcohol use, and drug use, with a 1.74-fold increased odds (95% CI 1.05-2.89, P = 0.032) of hepatitis C (HCV) among those with HS as compared to controls.
Conclusions:
This study demonstrated an association between HS and both hepatitis B and hepatitis C.
