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Influential Factors of Successful Hepatitis C Treatment in Elderly Patients

Jennifer Andres1, Mandee Noval1, Christine Mauriello1

  • 1Temple University School of Pharmacy.

Innovations in Pharmacy
|May 19, 2021
PubMed

Insights

Hepatitis C virus (HCV) treatment in elderly patients over 70 showed a 79% sustained virologic response (SVR12). Cirrhosis and older age were linked to treatment failure, highlighting the need for tailored HCV treatment strategies in this demographic.

Area of Science:

  • Hepatology
  • Geriatric Medicine
  • Infectious Diseases

Background:

  • Chronic Hepatitis C virus (HCV) infection increases risks for cirrhosis, hepatocellular carcinoma (HCC), and mortality.
  • Treating HCV in elderly patients presents unique challenges due to limited evidence and complex patient profiles.

Purpose of the Study:

  • To evaluate factors influencing Hepatitis C virus (HCV) treatment success in elderly patients (over 70).
  • Key factors assessed include pill burden, comorbidities, drug interactions, and adverse effects.

Main Methods:

  • Retrospective chart review of patients treated between 2014-2016 at an urban academic institution.
  • Included 62 patients aged 70 and above.

Main Results:

  • Achieved a 79% sustained virologic response rate 12 weeks post-treatment (SVR12).
  • Multivariate analysis identified cirrhosis, age closer to 70, and longer treatment duration as predictors of treatment failure.
  • Adverse events and drug interactions were frequent; cognitive impairment and cardiovascular disease may negatively impact SVR12.

Conclusions:

  • The SVR12 rate in this elderly cohort was lower than previously reported.
  • Cirrhosis is a significant factor associated with lower treatment success in elderly HCV patients.
  • Further research is needed to understand the impact of various factors on SVR12 attainment in older adults.
Abstract

Keywords:
Adverse EventsDrug InteractionsElderlyHepatitis CPolypharmacy

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