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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

[Immunotherapy for bladder cancer in 2021].

Christophe Cisarovsky¹, Sofiya Latifyan¹, Claire Perrinjaquet¹

¹Service d'oncologie médicale, Département d'oncologie, CHUV, 1011 Lausanne.

Revue Medicale Suisse

|May 19, 2021

Summary

Intravesical immunotherapy using Calmette-Guerin bacillus (BCG) has long treated bladder cancer. More recently, immune checkpoint inhibitors (ICI) show promise for advanced and localized bladder cancer, offering durable tumor control.

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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

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Area of Science:

Oncology
Immunology
Urology

Background:

Intravesical Calmette-Guerin bacillus (BCG) immunotherapy is a decades-long standard for non-muscle invasive bladder cancer.
This demonstrates immunotherapy's efficacy in treating bladder cancer.

Purpose of the Study:

To review the established role of BCG immunotherapy.
To highlight the emergence and impact of immune checkpoint inhibitors (ICI) in bladder cancer treatment.
To discuss the ongoing investigation of ICI for localized bladder cancer.

Main Methods:

Literature review of immunotherapy in bladder cancer treatment.
Analysis of clinical trial data for BCG and ICI efficacy.
Synthesis of current research on immune checkpoint inhibitors.

Main Results:

BCG immunotherapy has a proven track record for non-muscle invasive bladder cancer.
Immune checkpoint inhibitors (ICI) have shown significant clinical benefits since 2016 for advanced or metastatic bladder cancer.
ICI offer durable tumor control in various treatment settings, including first-line and post-relapse.

Conclusions:

Immunotherapy, including BCG and ICI, is a cornerstone in bladder cancer management.
ICI represent a significant advancement, expanding treatment options for advanced disease.
Research is actively exploring the potential of ICI for earlier stages of bladder cancer.