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Related Concept Videos

Compact Bone01:27

Compact Bone

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Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Updated: Nov 5, 2025

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Multifocal Xanthoma of Bone.

Eric M Schryver1, Martin G McCandless, Youssef Al Hmada

  • 1From the Department of Orthopedic Surgery Rehabilitation (Dr. Schryver, Mr. McCandless, Dr. Barr) and the Department of Pathology (Dr. Al Hmada), University of Mississippi Medical Center, Jackson, MS.

Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews
|May 19, 2021
PubMed
Summary
This summary is machine-generated.

Xanthoma of bone, a benign condition, can signal uncontrolled hyperlipidemia and elevate cardiovascular disease risk. This case highlights the need for prophylactic fixation of femurs to prevent fractures due to lytic bone lesions.

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Area of Science:

  • Orthopedic Surgery
  • Endocrinology
  • Cardiovascular Medicine

Background:

  • Hyperlipidemia is a significant risk factor for cardiovascular disease.
  • Xanthomas, typically associated with lipid disorders, can manifest in various tissues, including bone.
  • Bone xanthomas, though benign, may indicate underlying metabolic derangements.

Observation:

  • A 40-year-old woman presented with multifocal xanthoma of bone.
  • The bone lesions were associated with hyperlipidemia.
  • The patient required prophylactic fixation of bilateral femurs due to lytic bone lesions.

Findings:

  • Multifocal bone xanthomas can be a manifestation of poorly controlled hyperlipidemia.
  • Lytic bone lesions caused by xanthomas pose a risk of pathologic fracture.
  • Prophylactic surgical fixation may be necessary to prevent fractures in affected long bones.

Implications:

  • Bone xanthomas serve as a potential indicator of systemic lipid abnormalities.
  • Management of hyperlipidemia is crucial to mitigate cardiovascular risks.
  • Early recognition and intervention for bone xanthomas can prevent skeletal complications and fractures.