Squamous cell carcinoma of the sole in a patient with chronic graft-vs-host disease

Chronic graft-vs-host disease (GvHD) is a common, severe complication of bone marrow transplantation that often results in sclerodermoid skin changes with chronic and recurrent skin ulceration. We describe a case of cutaneous squamous cell carcinoma presenting as an ulcer on the sole of a 20-year-old woman with chronic GvHD. Although such an association has not been previously described, we discuss why features of chronic GvHD could be expected to place affected patients at increased risk for cutaneous squamous cell carcinoma.