Related Experiment Video
Updated: Nov 5, 2025
07:54
Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
Published on: March 25, 2019
8.4K
Size-transformable nanohybrids with pH/redox/enzymatic sensitivity for anticancer therapy.
Bozhen Wu1, Mingpei Li1, Liudi Wang2
1College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Journal of Materials Chemistry. B
|May 20, 2021
Summary
This study presents a novel nanocarrier system that enhances tumor penetration and drug delivery for cancer treatment. The pH/redox/enzymatic-sensitive nanohybrid system improves intracellular delivery and antitumor effects.
Area of Science:
- Biomedical Engineering
- Materials Science
- Oncology
Background:
- Limited clinical applications of nanocarriers in cancer therapy due to poor tumor penetration and low delivery efficiency.
- Tumor microenvironment (TME)-responsive drug delivery systems offer targeted drug release for improved therapeutic outcomes.
Purpose of the Study:
- To develop a biodegradable, multi-sensitive nanohybrid drug delivery system for enhanced cancer treatment.
- To investigate the TME-responsive drug release and combined therapeutic potential of the developed nanosystem.
Main Methods:
- Assembly of bovine serum albumin (BSA) nano-units onto graphene oxide (GO) nanosheets using gelatin.
- Characterization of nanoparticle stability under physiological conditions and drug release triggered by TME-specific stimuli (pH, redox, enzymes).
- Evaluation of combined chemotherapy (doxorubicin release) and photothermal therapy (near-infrared light) in a tumor model.
Main Results:
- The nanohybrid system demonstrated stability under physiological conditions and released BSA nano-units upon protease triggering.
- Acidic, reductive, and enzymatic TME conditions effectively triggered doxorubicin (DOX) release.
- The system facilitated combined chemotherapy and photothermal therapy, showing potential for enhanced antitumor bioactivity.
Conclusions:
- The developed pH/redox/enzymatic-sensitive nanohybrid system effectively targets the tumor microenvironment for controlled drug release.
- The nanosystem shows promise in improving tumor penetration, intracellular drug delivery, and combining chemotherapy with photothermal therapy for enhanced anticancer efficacy.
