Nanoscale Metal-Organic Frameworks: Recent developments in synthesis, modifications and bioimaging applications

Area of Science:

• Materials Science
• Chemistry
• Biomedical Engineering

Background:

• Porous Metal-Organic Frameworks (MOFs) are versatile materials with unique properties.
• MOFs are increasingly utilized in bioimaging for disease detection and diagnosis.
• Applications include detecting RNA, DNA, enzyme activity, and small biomolecules, alongside MRI and CT imaging.

Purpose of the Study:

• To present crucial parameters for designing efficient MOFs for bioimaging platforms.
• To provide a roadmap for researchers in MOF-based bioimaging.
• To discuss the influence of modifications on MOF performance and address challenges.

Main Methods:

• Review of existing literature on MOF synthesis and modification for bioimaging.
• Analysis of core structure, synthesis methods, and post-synthetic modifications.
• Discussion of applications in various bioimaging modalities.

Main Results:

• Optimal MOF performance in bioimaging is contingent upon core structure, synthesis, and modification.
• MOFs show promise for accurate and selective detection of abnormalities.
• Modifications significantly influence MOF performance in bioimaging applications.

Conclusions:

• MOFs are key materials for developing advanced bioimaging platforms.
• Careful design and modification are essential for efficient MOF-based bioimaging.
• Further research into advanced MOF synthesis and modification will drive future applications.