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Updated: Nov 4, 2025
Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
Published on: February 2, 2024
First case of periprosthetic joint infection due to Clostridioides difficile in China
Yang Song1, Hong Yi Shao1, Xiang Cheng2
1Department of Orthopaedic, Jishuitan Hospital and Fourth Medical College of Peking University, Beijing, China.
Background:
Clostridioides difficile usually causes intestinal infections. However, a 75-year-old lady had a periprosthetic joint infection due to this microorganism. We report a C. difficile infection of a prosthetic hip joint. Such an infection is rarely reported around the world.
Case Presentation:
The elder female patient presented with a 2-year history of right hip pain with movement restriction. Her right leg was shorter than another. The skin around the right hip joint was red and swollen without sinus. Her lab test result showed elevator ESR and CRP. Her X-ray film showed a massive bone defect. The patient had a total hip arthroplasty 16 years ago and had a revision 5 years ago. During this hospitalization, her cultures of the synovial fluid and tissue repeatedly grew C. difficile. She improved following two-stage revision surgery and antibiotic treatment. The patient has no recurrence of infection after a one-year follow-up.
Conclusion:
A rapid and accurate sample collection is significant for culture results, making an outstanding contribution to the successful treatment.
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