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Complete and Partial Aortic Occlusion for the Treatment of Hemorrhagic Shock in Swine
Published on: August 24, 2018
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Valproic Acid Protects Against Acute Kidney Injury in Hemorrhage and Trauma
Ben E Biesterveld1, Ali Z Siddiqui1, Rachel L O'Connell2
1Department of Surgery, University of Michigan, Ann Arbor, MI.
The Journal of Surgical Research
|May 23, 2021
Summary
Valproic acid (VPA) significantly improved survival and reduced kidney injury in swine models of trauma and shock. This study highlights VPA
Area of Science:
- Trauma and Emergency Medicine
- Nephrology
- Pharmacology
Background:
- Trauma is a leading cause of mortality in young individuals.
- Acute kidney injury (AKI) is a common complication in trauma patients, increasing mortality risk.
- Valproic acid (VPA) has demonstrated survival benefits in animal trauma models.
Purpose of the Study:
- To investigate the potential of VPA to attenuate AKI in swine models of lethal trauma.
- To evaluate the effect of VPA on survival rates and kidney function following severe injury.
Main Methods:
- Two swine models were used: hemorrhagic shock and polytrauma (including TBI, hemorrhage, fracture, crush, and liver laceration).
- Animals received normal saline (NS) with or without VPA (150 mg/kg) post-shock.
- Serum creatinine levels and kidney tissue proteomic analysis were performed.
Main Results:
- VPA treatment significantly improved survival in both models (80% vs. 20% and 83% vs. 17%).
- VPA administration attenuated the rise in serum creatinine levels in both hemorrhagic shock and polytrauma models.
- Proteomic analysis revealed VPA's impact on metabolic pathways within kidney tissue.
Conclusions:
- A single dose of VPA (150 mg/kg) provides significant protection against AKI in swine models of polytrauma and hemorrhagic shock.
- VPA demonstrates therapeutic potential for mitigating kidney injury in severe trauma scenarios.
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