Related Experiment Video
Updated: Nov 4, 2025
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
18.4K
Migraine in Chiari 1 Malformation: a cross-sectional, single centre study
Palma Ciaramitaro1, Eugenia Rota2, Marilena Ferraris3
1Centro Regionale Esperto Siringomielia e Sindrome di Chiari (CRESSC), Department of Neuroscience, AOU Città della Salute e della Scienza di Torino, Presidio CTO, Via Zuretti, 29, 10126, Turin, Italy. palma.ciaramitaro@gmail.com.
Acta Neurologica Belgica
|May 28, 2021
Summary
Migraine is common in Chiari 1 Malformation (CM1) patients, especially those with isolated CM1. Careful headache evaluation is recommended for CM1 patients to identify migraine.
Area of Science:
- Neurology
- Neurosurgery
Background:
- Chiari 1 Malformation (CM1) can present with various headache types, including migraine.
- Exertional headache is the most frequent symptom in CM1.
Purpose of the Study:
- To determine the prevalence of migraine in headache patients with CM1.
- To compare clinical-demographic characteristics between migraine and non-migraine CM1 patients.
- To investigate the association between CM1 phenotypes and migraine.
Main Methods:
- Cross-sectional study involving 427 adults at a multidisciplinary Chiari Center.
- 230 headache patients were classified based on radiological criteria.
- Logistic regression models were used to assess associations between CM1 diagnosis, headache characteristics, and migraine.
Main Results:
- 34% of CM1 headache patients had migraine (56% with aura).
- Migraine was comorbid with CM1-related secondary headache in 74% of migraineurs.
- Migraine prevalence was significantly higher in isolated CM1 (43.3%) compared to other CM1 phenotypes (23.6%).
- Isolated CM1 phenotype was associated with migraine (OR=2.6).
Conclusions:
- Migraine is highly prevalent in CM1 patients.
- A significant association exists between migraine and isolated CM1.
- Clinical characterization of headaches in CM1 patients, per International Headache Society criteria, is advised, particularly for those without neurological signs.
