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Updated: Nov 4, 2025

Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy
Published on: December 16, 2021
Arginine methylation and cytoplasmic mRNA fate: An exciting new partnership
Sabnam Parbin1,2, Subha Damodharan1, Purusharth I Rajyaguru1
1Department of Biochemistry, Indian Institute of Science, Bangalore, India.
Abstract:
Posttranslational modifications play a crucial role in regulating gene expression. Among these modifications, arginine methylation has recently attracted tremendous attention due to its role in multiple cellular functions. This review discusses the recent advances that have established arginine methylation as a major player in determining cytoplasmic messenger RNA (mRNA) fate. We specifically focus on research that implicates arginine methylation in regulating mRNA translation, decay, and RNA granule dynamics. Based on this research, we highlight a few emerging future avenues that will lead to exciting discoveries in this field.
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