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One-step Protocol for Evaluation of the Mode of Radiation-induced Clonogenic Cell Death by Fluorescence Microscopy
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Induced Cell Death as a Possible Pathway of Antimutagenic Action

N V Eremina1, A K Zhanataev1, A D Durnev2

  • 1V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.

Bulletin of Experimental Biology and Medicine
|May 29, 2021
PubMed

Insights

Certain compounds, including polyphenols like resveratrol and curcumin, show antimutagenic and pro-apoptotic effects. This suggests that programmed cell death may serve as a mechanism for antimutagenesis.

Area of Science:

  • Molecular Biology
  • Genetics
  • Pharmacology

Background:

  • Antimutagenesis research explores compounds that prevent DNA mutations.
  • Polyphenols and other natural compounds are investigated for their biological activities.
  • Apoptosis, or programmed cell death, is a crucial cellular process.

Purpose of the Study:

  • To review existing concepts of antimutagenesis.
  • To discuss the antimutagenic and pro-apoptotic properties of various compounds.
  • To explore the relationship between these two properties.

Main Methods:

  • Literature review of published reports.
  • Analysis of in vitro and in vivo experimental data.
  • Focus on eukaryotic test systems.

Main Results:

  • Several polyphenols (e.g., naringin, apigenin, resveratrol, curcumin) and N-acetylcysteine exhibit both antimutagenic and pro-apoptotic effects.
  • Data from diverse eukaryotic test systems support these findings.

Conclusions:

  • A strong correlation exists between the antimutagenic and pro-apoptotic activities of the studied compounds.
  • Induced cell death is proposed as a significant mechanism underlying antimutagenesis.
Keywords:
antimutagenesisantimutagenscell deathmutagenesis

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