Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Analgesia and Pain Management

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

Pain

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Myoelectric and Progressive Motor Training for Phantom Limb Pain in People with Amputations During War: A Feasibility Report.

Journal of pain research·2026

Same author

Locomotion Decoding (<i>LocoD</i>): An Open-Source and Modular Platform for Researching Control Algorithms for Lower Limb Assistive Devices.

Applied bionics and biomechanics·2026

Same author

Theoretical foundations of Progressive Motor Training (PMT) for Phantom Limb Pain.

Journal of neuroengineering and rehabilitation·2026

Same author

Engineering a Quality Management System for Academic Research: Navigating Challenges to Comply with the New Medical Device Regulations in Europe.

Medical devices (Auckland, N.Z.)·2025

Same author

Evaluating Mirror Therapy Protocols in Phantom Limb Pain Clinical Trials: A Scoping Review.

Journal of pain research·2025

Same author

Reducing phantom limb pain using phantom motor execution enabled by augmented and virtual reality: participants' perspectives on an innovative treatment.

Disability and rehabilitation·2024

Search research articles

Related Experiment Video

Updated: Nov 4, 2025

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

Mathematical and Computational Models for Pain: A Systematic Review.

Victoria Ashley Lang^1,2, Torbjörn Lundh^1,3,4, Max Ortiz-Catalan^1,2,5,6

¹Center for Bionics and Pain Research, Sweden.

Pain Medicine (Malden, Mass.)

|May 29, 2021

Summary

Mathematical and computational models for pain are understudied. This review found most models classify pain, but future research should focus on mechanisms for better diagnostics and treatment.

Keywords:

Computational Biology Mathematical Model Pain Mechanism Pain Model

More Related Videos

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram

Published on: July 7, 2023

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

Related Experiment Videos

Last Updated: Nov 4, 2025

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram

Published on: July 7, 2023

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

Area of Science:

Computational neuroscience
Pain research
Mathematical modeling

Background:

Current pain theories are incomplete, lacking a unified explanation for pain's origin, qualities, and alleviation.
While molecular targets are studied, few computational or mathematical models explore pain's underlying mechanisms or etiology.

Purpose of the Study:

To systematically identify and classify existing mathematical and computational models used for characterizing pain.
To assess the current state and future potential of computational approaches in pain research.

Main Methods:

A systematic literature search was conducted on Science Direct and PubMed.
Searched articles published before January 1st, 2020.
Included articles that incorporated mathematical or computational models of pain, resulting in 31 relevant studies.

Main Results:

The majority of reviewed studies employed classification algorithms to distinguish between pain and no-pain states.
The literature predominantly focuses on applying existing models or machine learning for pain detection, rather than exploring pain's diagnostic or therapeutic features.

Conclusions:

Mathematical models offer a promising avenue to enhance pain understanding by guiding testable hypotheses on pain mechanisms.
Further development of models focused on elucidating pain's underlying mechanisms is crucial for potential treatment breakthroughs.