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Hypertension and Heart Failure with Preserved Ejection Fraction
1Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
Heart Failure Clinics
|May 30, 2021
Summary
Heart failure with preserved ejection fraction (HFpEF) is rising, with hypertension as a key factor. This review explores hypertension
Area of Science:
- Cardiology
- Nephrology
- Internal Medicine
Background:
- Heart failure with preserved ejection fraction (HFpEF) prevalence is increasing.
- HFpEF shares a poor prognosis with heart failure with reduced ejection fraction (HFrEF).
- Hypertension is a significant risk factor in HFpEF pathophysiology.
Purpose of the Study:
- To discuss the pathophysiological mechanisms linking hypertension and HFpEF.
- To review current evidence on managing hypertension in HFpEF patients.
Main Methods:
- Literature review of pathophysiological mechanisms.
- Analysis of clinical trial data and observational studies on hypertension treatment in HFpEF.
Main Results:
- Hypertension contributes to cardiac remodeling and diastolic dysfunction in HFpEF.
- Evidence on optimal hypertension treatment in HFpEF remains conflicting, requiring further research.
Conclusions:
- Understanding the hypertension-HFpEF link is crucial for developing targeted therapies.
- Personalized treatment strategies for hypertension in HFpEF are needed to improve patient outcomes.
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