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Published on: August 30, 2007
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Reversible control of biomaterial properties for dynamically tuning cell behavior
Fallon M Fumasi1, Nicholas Stephanopoulos2,3, Julianne L Holloway1,2
1Chemical Engineering, School for Engineering of Matter Transport and Energy, Arizona State University, Tempe, Arizona.
Journal of Applied Polymer Science
|May 31, 2021
Summary
Researchers review advances in dynamic biomaterials, focusing on reversible control of material properties like stiffness and chemistry. These innovative materials offer new possibilities for biomedical engineering applications, including disease modeling and tissue regeneration.
Area of Science:
- Biomaterials Science
- Chemical Engineering
- Biomedical Engineering
Background:
- Recent decades have seen significant progress in chemistry and manufacturing, leading to complex and controllable biomaterials.
- A key development is dynamic biomaterials offering user-specified, reversible temporal control over material properties.
Purpose of the Study:
- To provide an overview of recent advancements in reversible biomaterials.
- To highlight the control over material properties such as stiffness, chemistry, ligand presentation, and topography.
- To discuss the wide-ranging applications of these dynamic biomaterials in biomedical engineering.
Main Methods:
- Literature review of recent advancements in reversible biomaterials.
- Analysis of control mechanisms for material properties (stiffness, chemistry, ligand presentation, topography).
- Exploration of applications in biomedical engineering.
Main Results:
- Dynamic biomaterials enable precise, reversible control over key material properties.
- Advancements include tunable stiffness, adaptable chemistry, controlled ligand presentation, and dynamic topography.
- These materials are crucial for developing sophisticated in vitro disease models and advanced tissue-engineered scaffolds.
Conclusions:
- Reversible biomaterials represent a significant innovation in materials science.
- These materials facilitate the guidance of complex, multistep biological processes.
- Applications in disease modeling and tissue engineering are expanding due to these controllable systems.
