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Updated: Nov 3, 2025
08:29
Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel
Published on: May 14, 2018
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Paclitaxel-Based Chemotherapy Targeting Cancer Stem Cells from Mono- to Combination Therapy
Hend M Nawara1, Said M Afify1,2, Ghmkin Hassan1,3
1Department of Biotechnology and Drug Discovery, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama 700-8530, Japan.
Biomedicines
|June 2, 2021
Summary
Paclitaxel (PTX) is a vital chemotherapy drug that targets microtubules to fight cancer. Overcoming cancer resistance to PTX is crucial, and combining it with other agents offers promising therapeutic strategies.
Area of Science:
- Oncology
- Pharmacology
- Molecular Biology
Background:
- Paclitaxel (PTX) is a widely used chemotherapy agent for various cancers.
- Its primary mechanism involves disrupting microtubule dynamics, leading to mitotic arrest and cell death.
- Cancer resistance to PTX presents a significant clinical challenge, contributing to treatment failure.
Purpose of the Study:
- To summarize the known mechanisms of Paclitaxel (PTX).
- To review current research on PTX's anticancer activity and resistance.
- To explore promising combination therapies involving PTX.
Main Methods:
- Literature review of studies on Paclitaxel (PTX) mechanisms.
- Analysis of research on PTX resistance in cancer.
- Compilation of data on PTX combination therapies.
Main Results:
- PTX effectively targets microtubules, inducing cancer cell death.
- Cancer resistance to PTX is a major obstacle in treatment.
- Combination therapies show potential for enhanced efficacy.
Conclusions:
- Understanding PTX mechanisms and resistance is key to improving cancer treatment.
- Combining PTX with other drugs offers a promising strategy to overcome resistance.
- Further research into PTX combinations is warranted for clinical application.
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