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Proceedings of the 2020 GRAPPA Collaborative Research Network (CRN) Meeting
Carmel Stober1, Deepak R Jadon2, April W Armstrong3
1C. Stober, MBChB, MRCP, PhD, MSc, Department of Medicine, University of Cambridge, Cambridge, UK.
The Journal of Rheumatology. Supplement
|June 2, 2021
Summary
The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) is piloting new methods to evaluate biomarkers for axial psoriatic arthritis (PsA). Progress on studies predicting structural damage, disease development, and treatment response was also shared.
Area of Science:
- Rheumatology and immunology research focused on psoriatic arthritis (PsA).
- Biomarker discovery and validation for disease prediction and treatment response.
Background:
- Psoriatic arthritis (PsA) presents challenges in predicting disease progression and treatment outcomes.
- The need for standardized methods to evaluate biomarkers in PsA, particularly for axial disease.
Framework:
- Pilot study protocol for electronic case report forms (eCRFs) and Standardized Operating Procedures (SOPs) for biomarker evaluation in axial PsA.
- Development of a collaborative research network (CRN) framework for multi-center studies.
Implementation:
- Presentation of progress on three key studies: BioDAM PsA (biomarker validation for structural damage), PreventPsA (risk factors for PsA development), and PredictORPsA (biomarkers for treatment response in early PsA).
- Ongoing funding applications and partnerships with Innovative Medicines Initiative (IMI) and Accelerating Medicines Partnerships (AMP) 2.0.
Implications:
- Advancing the understanding and management of psoriatic arthritis through biomarker research.
- Establishing standardized protocols for future PsA research and clinical trials.
- Potential for improved prediction of disease outcomes and personalized treatment strategies in PsA.
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