Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

5.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic Factors in Primary Head and Neck Cutaneous Squamous Cell Carcinoma: A Large-Scale, Multi-Institutional Competing-Risks Analysis.

Journal of surgical oncology·2026
Same author

Consensus Guidelines for Staging and Surveillance Imaging in Cutaneous Squamous Cell Carcinoma.

JAMA dermatology·2026
Same author

Mohs micrographic surgery versus wide local excision for recurrent cutaneous squamous cell carcinoma.

JAAD international·2026
Same author

Quantitative Assessment of the Correlation Between 'COVID Toes' Search Volume and COVID-19 Case Incidence and Mortality Dynamics: A Longitudinal Data-Driven Approach.

Journal of the American Podiatric Medical Association·2026
Same author

Comparing the i31-SLNB and the MIA Nomogram for Sentinel Lymph Node Biopsy Positivity Prediction in Cutaneous Melanoma: A Prospective Cohort Analysis.

Dermatology and therapy·2026
Same author

Development of a Core Outcome Domain Set for Facial Aging.

JAMA dermatology·2026

Related Experiment Video

Updated: Nov 3, 2025

Establishment of a Clinic-based Biorepository
07:50

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

6.7K

Clinical Considerations for Integrating Gene Expression Profiling into Cutaneous Squamous Cell Carcinoma Management.

Sarah T Arron, Travis W Blalock, J Michael Guenther

    Journal of Drugs in Dermatology : JDD
    |June 2, 2021
    PubMed
    Summary

    Gene expression profile (GEP) testing aids in predicting metastatic risk for high-risk cutaneous squamous cell carcinoma (CSCC). This framework guides clinicians on integrating GEP results into nodal evaluation, radiation therapy, and surveillance decisions.

    More Related Videos

    Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
    09:08

    Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

    Published on: October 14, 2021

    5.8K
    In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
    07:52

    In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity

    Published on: November 2, 2020

    6.7K

    Related Experiment Videos

    Last Updated: Nov 3, 2025

    Establishment of a Clinic-based Biorepository
    07:50

    Establishment of a Clinic-based Biorepository

    Published on: May 29, 2017

    6.7K
    Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
    09:08

    Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

    Published on: October 14, 2021

    5.8K
    In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
    07:52

    In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity

    Published on: November 2, 2020

    6.7K

    Area of Science:

    • Oncology
    • Dermatology
    • Genomics

    Background:

    • Cutaneous squamous cell carcinoma (CSCC) poses a metastatic risk, especially in high-risk patients.
    • Gene expression profile (GEP) testing is a new tool for assessing this risk.

    Purpose of the Study:

    • To establish a framework for integrating GEP testing into clinical practice for CSCC management.
    • To guide healthcare providers in utilizing patient-specific tumor biology for treatment decisions.

    Main Methods:

    • An expert panel convened to identify clinical decision points for GEP testing in CSCC.
    • Focus areas included nodal evaluation, adjuvant radiation therapy, and follow-up strategies.
    • The framework is intended for use until prospective trial data is definitive.

    Main Results:

    • GEP testing can inform decisions regarding nodal evaluation in high-risk CSCC.
    • The results can aid in determining the need for adjuvant radiation therapy.
    • GEP testing provides an additional data point for surveillance and follow-up planning.

    Conclusions:

    • GEP testing should supplement, not replace, standard of care for high-risk CSCC.
    • Individualized management plans benefit from incorporating GEP prognostic data.
    • Multidisciplinary input is crucial for optimal CSCC patient management decisions.