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Serum Elemental Analysis of Type 2 Diabetes Patients Using SRXRF.
N Srinivasa Rao1, G J Naga Raju2, M K Tiwari3
1Department of Physics, GIS, GITAM Deemed To Be University, Visakhapatnam, 530045, India.
Biological Trace Element Research
|June 2, 2021
Summary
Serum elemental analysis revealed significant differences in type 2 diabetes patients. Altered levels of key elements may impact insulin function and glucose homeostasis, potentially through oxidative stress.
Area of Science:
- Biochemistry
- Analytical Chemistry
- Medical Physics
Background:
- Type 2 diabetes is a complex metabolic disorder with multifactorial etiology.
- Elemental imbalances have been implicated in various chronic diseases, including diabetes.
Purpose of the Study:
- To investigate elemental concentration differences in serum of type 2 diabetes patients versus healthy controls.
- To explore potential correlations between elemental alterations and diabetes pathophysiology.
Main Methods:
- Serum samples from 158 individuals (type 2 diabetes patients and controls) were analyzed.
- Synchrotron Radiation X-ray Fluorescence (SRXRF) technique was employed for elemental quantification.
- Specific elements analyzed included K, Ca, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Br, Rb, Sr, and Pb.
Main Results:
- Significant decreases in serum K, Ca, Ti, Cr, Mn, Ni, Zn, and As were observed in type 2 diabetes patients.
- Significant increases in serum V, Fe, Co, Cu, Se, and Pb were noted in the patient group.
- Elemental concentration patterns differed notably between patients and controls.
Conclusions:
- Observed elemental alterations in type 2 diabetes patients suggest a potential role in disease development.
- Hypothesized mechanisms include interference with insulin uptake and glucose homeostasis.
- These changes may be linked to oxidative stress pathways.
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