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Progress and lack of progress in hyperhidrosis research 2015-2020. A concise systematic review
Johannes Kjeldstrup Kristensen1, Corina Nielsen1
1Skin and Hyperhidrosis Clinic, Copenhagen, Denmark.
International Journal of Dermatology
|June 3, 2021
Summary
Research on hyperhidrosis shows limited progress in diagnosis and treatment over the last five years. Despite numerous studies, many lack quality, and key trials remain unperformed, indicating the condition is still under-studied.
Area of Science:
- Dermatology
- Medical Research
Background:
- Hyperhidrosis, excessive sweating, significantly impairs quality of life and is linked to psychiatric conditions.
- Current understanding and management of hyperhidrosis face challenges due to limited high-quality research.
Purpose of the Study:
- To systematically review research on hyperhidrosis published between July 2015 and July 2020.
- To assess progress in hyperhidrosis diagnosis, etiology, epidemiology, and treatment interventions.
Main Methods:
- Systematic review of five databases (July 2015-July 2020).
- Inclusion of high-quality research articles, including randomized clinical trials (RCTs).
- Narrative synthesis of findings, with trial quality assessed using the Cochrane risk-of-bias tool.
Main Results:
- Twenty-nine papers were included, varying significantly in quality, population, intervention, and outcome assessment.
- Most studies, including RCTs, were small and at high risk of bias.
- Limited high-quality evidence was found for diagnosis, epidemiology, and etiology; treatment progress also remains restricted.
Conclusions:
- Progress in hyperhidrosis diagnostics, etiology, and treatment remains limited over the past five years.
- Despite previous recommendations, comparative trials (e.g., botulinum toxin vs. iontophoresis for palmar hyperhidrosis) have not been conducted.
- Hyperhidrosis continues to be an under-studied condition with a significant impact on patients' lives.
