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Conventional cardiovascular risk factors associated with Takotsubo cardiomyopathy: A comprehensive review

Jing Liang1, Jingyi Zhang1, Yidan Xu2

  • 1Human Anatomy Laboratory, School of Basic Medicine, Xinxiang Medical University, Henan, China.

Clinical Cardiology
|June 3, 2021
PubMed

Insights

Conventional cardiovascular risk factors like hypertension and obesity impact Takotsubo cardiomyopathy (TCM) outcomes, particularly mortality and complications. Further research is needed to fully understand these associations.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Takotsubo cardiomyopathy (TCM) is a condition of transient left ventricular dysfunction.
  • Research on TCM, first reported in 1990, is growing but remains limited.
  • Conventional cardiovascular factors may influence TCM development and prognosis.

Purpose of the Study:

  • To review and summarize current evidence on the correlation between conventional cardiovascular risk factors and Takotsubo cardiomyopathy.
  • To analyze the impact of these factors on TCM outcomes, including mortality and complications.

Main Methods:

  • A literature review of publications in the PubMed database.
  • Publications were selected from January 1, 2010, to January 15, 2021.
  • The review focused on the association between TCM and hypertension, diabetes, hyperlipidemia, and obesity.

Main Results:

  • TCM predominantly affects postmenopausal women; men and younger patients face higher risks of adverse complications.
  • Hypertension is common in recurrent TCM. Obesity and chronic kidney disease are linked to poorer TCM prognosis.
  • Hyperlipidemia may be associated with fewer complications, but evidence is limited. The link between diabetes and TCM prognosis is unclear.

Conclusions:

  • Conventional cardiovascular risk factors are associated with Takotsubo cardiomyopathy outcomes, especially mortality and complications.
  • Obesity and chronic kidney disease appear to worsen TCM prognosis.
  • More prospective studies are required to elucidate the precise relationship between specific risk factors and TCM prognosis.

Keywords:
Takotsubo cardiomyopathyagecardiovascular risk factorschronic kidney diseasediabetesgenderhyperlipidemiahypertensionobesity

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