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Related Concept Videos

Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

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Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
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Related Experiment Video

Updated: Nov 3, 2025

Production of Elastin-like Protein Hydrogels for Encapsulation and Immunostaining of Cells in 3D
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Genetically Encoded Elastin-Like Polypeptides for Drug Delivery.

Irene C Jenkins1, Joshua J Milligan1, Ashutosh Chilkoti1

  • 1Department of Biomedical Engineering, Duke University, Durham, NC, 277018, USA.

Advanced Healthcare Materials
|June 3, 2021
PubMed
Summary
This summary is machine-generated.

Elastin-like polypeptides (ELPs) are smart biopolymers that form advanced drug delivery systems. Their unique temperature-responsive nature enables precise control over biomaterial properties for targeted therapies.

Keywords:
drug deliveryelastin-like polypeptidesinjectable depotsnanoparticlesself-assemblysustained releasethermally responsive

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Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro
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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Elastin-like polypeptides (ELPs) are thermally responsive biopolymers based on human tropoelastin.
  • ELPs exhibit temperature-dependent phase behavior, enabling stimuli-responsive material formation.
  • Genetically encoded ELPs offer precise control over biomaterial properties, surpassing synthetic polymers.

Purpose of the Study:

  • To review the application of ELPs in developing advanced drug delivery systems.
  • To highlight the design of ELP architectures for controlled therapeutic delivery.
  • To discuss the potential of ELPs in treating diseases and promoting wound healing.

Main Methods:

  • Designing unique ELP architectures (micelles, coacervates) by manipulating amino acid sequence and length.
  • Incorporating drugs into ELP-based systems for controlled release.
  • Leveraging ELPs' biodegradable and nonimmunogenic properties for therapeutic applications.

Main Results:

  • ELPs can form nanoparticles and injectable depots for stimuli-responsive drug delivery.
  • Precise control over ELP architecture allows for tailored drug loading and release kinetics.
  • ELP-based systems demonstrate potential in treating cancer, diabetes, and in wound healing.

Conclusions:

  • ELPs are versatile, biodegradable, and nonimmunogenic biopolymers ideal for intelligent drug delivery.
  • ELP-based biomaterials offer precise control and advanced functionalities for therapeutic applications.
  • ELPs represent a promising platform for next-generation therapeutics and regenerative medicine.