Establishment of anti-oxidation platform based on few-layer molybdenum disulfide nanosheet-coated titanium dioxide...

The nanozyme-based antioxidant system could protect normal cells from oxidative stress due to their reactive oxygen species (ROS) scavenging activity and good chemical stability. However, its use is limited for practical in vivo applications due to the high cost and poor biocompatibility (low catalytic efficiency). Herein, MoS₂ decorated on TiO₂ nanobelts (MoS₂@TiO₂) was prepared for antioxidation applications. The as-prepared MoS₂@TiO₂ heterostructure with 50 wt% MoS₂ showed the highest efficient catalase activity and superoxide dismutase (SOD) activity under normal physiological conditions. The composite was superior to its single component in terms of enhanced dispersibility and catalytic performance resulting from the higher surface specific area and more exposed active sites. MoS₂@TiO₂ was not only confirmed to have good in vitro and in vivo biocompatibility but can also effectively eliminate the endogenous excessive accumulation of ROS caused by oxidative stress using the fibroblast cell (L929) line as a model. Further experiments confirmed that in the established mouse oxidative stress model, MoS₂@TiO₂ can quickly restore the ROS to a normal level in the oxidative stress site of the mouse. These results indicated that MoS₂@TiO₂ enzyme-like nanomaterials can provide a huge therapeutic potential in future antioxidant defence applications.