Experimental resin-modified calcium-silicate cement containing N-(2-hydroxyethyl) acrylamide monomer for pulp tissue
Mariano S Pedano1, Kumiko Yoshihara2, Xin Li1
1KU Leuven (University of Leuven), Department of Oral Health Sciences, BIOMAT - Biomaterials Research group & UZ Leuven (University Hospitals Leuven), Dentistry, Leuven, Belgium.
Summary
Innovative resin-modified calcium-silicate cements (Rm-CSCs) show improved physical properties and calcium release. Exp_HEAA demonstrated superior performance, including pulp-healing initiation in direct contact with dental pulp tissue.
Area of Science:
- Dental Materials Science
- Biomaterials Engineering
- Regenerative Dentistry
Background:
- Pulp capping requires materials that promote healing and possess favorable physical properties.
- Resin-modified calcium-silicate cements (Rm-CSCs) offer potential advantages over traditional materials.
- Optimizing Rm-CSC formulations is crucial for enhancing their clinical efficacy.
Purpose of the Study:
- To evaluate the flexural strength, shear bond strength to dentin, pH, and calcium release of novel Rm-CSCs.
- To assess the pulp-healing initiation capacity of these cements using an ex-vivo human vital tooth-culture model.
- To compare the performance of experimental Rm-CSCs against a commercial reference material.
Main Methods:
- Three experimental Rm-CSCs were formulated with varying hydrophilic monomers (HEAA, GDM) and a common base composition including UDMA, 4-MET, and FAM-401.
- Tricalcium silicate powder (TCS) and zirconium oxide (ZrO2) were incorporated as calcium source and radiopacifier.
- Physical properties, pH, and calcium release were measured, alongside an ex-vivo assessment of pulp-healing initiation.
Main Results:
- All experimental Rm-CSCs exhibited significantly higher flexural strength and shear bond strength to dentin compared to TheraCal LC.
- Exp_HEAA showed significantly higher calcium release and pH at 24 hours and 1 week compared to other tested cements.
- Exp_HEAA demonstrated pulp-healing initiation capacity, evidenced by nestin and collagen-I expression in the ex-vivo model.
Conclusions:
- The innovative Rm-CSCs exhibit favorable properties for pulp capping, including enhanced strength, bonding, and bioactivity.
- Exp_HEAA, formulated with a hydrophilic acrylamide monomer and 4-MET, showed promising pulp-healing initiation.
- The combination of specific monomers and tricalcium silicate powder in Exp_HEAA contributes to its superior performance and potential for regenerative endodontics.
