Redesign of computerized decision support system to improve Non Vitamin K oral anticoagulant prescribing-A pre and...

Inappropriate prescribing of non-vitamin K agents (NOAC) contributes to significant economic and personal burden to our society. Studies have shown that when well designed and targeted, computerized alerts can be effective in improving prescribing without contributing to alert fatigue.

A collaborative multidisciplinary review group was set up to review and endorse an upgrade and modification to the hospital electronic medication management system (EMS). The intervention focused on implementing tailored electronic patient specific physiological alerts (such as age, renal function weight and drug interactions) built in EMS to improve the appropriateness of NOAC prescribing at this multisite teaching Australian hospital. To assess the qualitative and quantitative impact of the intervention, a pre and post retrospective study of NOAC prescribing of 100 patients' pre and post the implementation stage was conducted in a multisite Australian 650 bed hospital. Appropriateness of NOAC prescribing was assessed by an experienced pharmacist using approved prescribing product information recommendations. Prescriber satisfaction and experience survey was assessed in both stages of the study using a standard satisfaction survey. Associated hospital acquired complications (HAC) with potential inappropriate NOAC prescribing were evaluated as well as related admission cost and average length of stay.

Redesign of computerised decision support in EMS improved appropriateness of NOAC prescribing from 48 % to 91 %, P < 0.05. A total of 67 prescribers accepted the invitation to participate in the qualitative satisfaction study. Half the respondents (n = 33, 50 %) answered positively to a question assessing the usefulness of implementing NOAC alerts in the EMS in improving their practice and patient safety. This rate has increased to 72 % (n = 48) in the post intervention phase. P < 0.05. Additionally, the total number of reported HAC that are likely to be associated with inappropriate NOAC prescribing was reduced by 36 % in the post intervention phase (from 29 to 22 (RR = 0.7454 95 %CI (0.4283-1.2972), P = 0.2986). The cost of associated HAC has also reduced by 29 % (from $1,282,748 to $911,117) as well as the mean length stay by 11 % (from 18 days to 16 days) post the intervention phase.

This study highlights that well-designed electronic prescribing alerts that provide context-relevant information to prescribers are likely to result in benefits to clinicians and patients as well reduction in economic burden. Moreover, they could also contribute to reducing hospital acquired complications and lessen the economic burden on our society.