The Role of Kallikrein10 (KLK10) Polymorphism in Prostate Cancer Susceptibility
Seda Güleç Yılmaz1, Faruk Yencilek2, Asıf Yıldırım3
1DDepartment of Medical Biology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey. seda.gulec@yeditepe.edu.tr.
Purpose:
The present study aims to investigate the potential role of Kallikrein 10 (KLK10) genotype and allele frequencies in predisposition to prostate cancer.
Materials And Methods:
KLK10 (rs7259451) gene polymorphisms were determined by real-time polymerase chain reaction analysis in patients with prostate cancer (n=69) and controls (n=76).
Results:
KLK10 gene frequencies were significantly different in the case and control groups (P = .028). GG carriers were significantly higher in the control group (P = .034), whereas TT carriers were higher in the prostate cancer group (P = .033). Furthermore, The patients with GG genotype had the lowest PSA levels while TT carriers had the highest (P = .005).
Conclusion:
According to the results, we suggested that carrying variant T allele and also carrying homozygote TT genotype could be a potential risk, while ancestral homozygote GG genotype and G allele are risk reducing factors for prostate cancer.
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