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Updated: Nov 2, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Visible-light mediated carbonyl trifluoromethylative amination as a practical method for the synthesis of
Kavoos Kolahdouzan1, Roopender Kumar1, Matthew J Gaunt1
1Department of Chemistry, University of Cambridge Lensfield Road Cambridge CB2 1EW UK mjg32@cam.ac.uk.
Abstract:
We report the development of an operationally straigtforward, visible-light-mediated multicomponent strategy for the construction of β-trifluoromethylated tertiary alkylamines from feedstock aldehydes, secondary amines and a convenient source of trifluoromethyl iodide. The new process does not require a photocatalyst, is metal-free, displays a broad functional group tolerance and offers rapid, one-pot access to trifluoromethylated drug-like compounds that will be of interest in medicinal chemistry.
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