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Apremilast Uses and Relevance to the Military
Nathanael E Hathaway1, Willis Hughes Lyford1
1Department of Dermatology, Naval Medical Center San Diego, California.
Cutis
|June 7, 2021
Summary
Apremilast offers a valuable oral treatment option for plaque psoriasis and psoriatic arthritis, particularly benefiting military personnel. This review highlights its efficacy and favorable use in specific patient populations.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Apremilast, a small-molecule phosphodiesterase 4 inhibitor, is FDA-approved for plaque psoriasis, psoriatic arthritis, and Behçet disease.
- While newer injectable biologics dominate psoriasis treatment, apremilast remains a crucial oral therapeutic option.
Observation:
- This review examines the on-label and off-label applications of apremilast.
- It specifically emphasizes the drug's significance in managing psoriasis within the military population.
- A case report illustrates the benefits of apremilast for service members.
Findings:
- Apremilast provides an important therapeutic avenue for psoriasis management, especially in contexts where injectable biologics may be less suitable.
- The drug demonstrates favorable outcomes in specific patient groups, including military personnel.
Implications:
- Apremilast represents a key treatment strategy for certain inflammatory conditions, offering an oral alternative to injectables.
- Its utility extends to specialized populations, underscoring the need for personalized treatment approaches in dermatology.
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