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A country-specific FRAX model for Botswana.

M Kebaetse1, S Nkhwa1, M Mogodi1

  • 1Faculty of Medicine, University of Botswana, Gaborone, Botswana.

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|June 8, 2021
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Summary

A new FRAX® model for Botswana was developed to assess fracture risk. This tool is expected to aid in preventing and treating fragility fractures across the nation.

Keywords:
BotswanaEpidemiologyFRAXFracture probabilityHip fractureMajor osteoporotic fracture

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Area of Science:

  • Public Health
  • Epidemiology
  • Orthopedics

Background:

  • Osteoporotic fractures pose a significant health burden globally.
  • Country-specific fracture risk assessment tools are crucial for targeted interventions.
  • Botswana previously lacked a localized FRAX® model for fracture risk assessment.

Purpose of the Study:

  • To develop and characterize a country-specific FRAX® model for Botswana.
  • To enable accurate fracture risk assessment for the Botswana population.
  • To inform public health strategies for osteoporosis management in Botswana.

Main Methods:

  • Incorporated age-specific and sex-specific hip fracture incidence data for Botswana.
  • Utilized national mortality rates in the FRAX® model development.
  • Compared 10-year fracture probabilities with existing FRAX® models from other African nations and US populations.

Main Results:

  • Developed a FRAX® model tailored to Botswana's demographic and epidemiological profile.
  • Fracture probabilities in Botswana were found to be lower than in South Africa (Black and Coloured) and US Blacks.
  • Probabilities were marginally higher compared to Tunisia, indicating a unique risk profile.

Conclusions:

  • The newly developed FRAX® model for Botswana provides a vital tool for fracture risk assessment.
  • This model is anticipated to significantly guide clinical decisions regarding the prevention and treatment of fragility fractures in Botswana.
  • Facilitates evidence-based strategies for managing osteoporosis and reducing fracture incidence.