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Longitudinal Risk Management for Patients with Increased Risk for Breast Cancer.
Malcolm Su1, Victoria Huynh1, Michael Bronsert2
1Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
The Journal of Surgical Research
|June 8, 2021
Summary
Women with gene mutations, high-risk proliferative changes, or prior hysterectomy were more likely to choose risk-reducing breast cancer strategies. These factors can guide shared decision-making for high-risk patients.
Area of Science:
- Oncology
- Genetics
- Preventive Medicine
Background:
- Breast cancer risk assessment identifies women needing proactive management.
- Understanding factors influencing risk-reducing behavior is crucial for personalized care.
Purpose of the Study:
- To characterize longitudinal care management for high-risk breast cancer patients.
- To evaluate patient factors associated with choosing risk-reducing behaviors like chemoprevention or prophylactic mastectomy.
Main Methods:
- Retrospective study of 283 adult female patients assessed for breast cancer risk.
- Time-to-event analysis used to determine hazard ratios for pursuing risk-reducing care.
Main Results:
- 17.0% of patients pursued risk-reducing strategies.
- Gene mutations (HR 5.99), high-risk proliferative changes (HR 7.62), and hysterectomy (HR 2.99) significantly increased likelihood of risk-reducing management.
- Age, race, and predicted breast cancer risk were not associated with strategy adoption.
Conclusions:
- Gene mutations, high-risk proliferative changes, and prior hysterectomy are key predictors of risk-reducing strategy adoption.
- Integrating these findings with patient-reported outcomes can enhance shared decision-making for breast cancer prevention.
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