[IMMUNE DISORDERS AND THEIR ROLE IN ABORTION]

Objective of the study - to identify the relationship of immunological parameters and their role in termination of pregnancy. 28 women, with a history of 2 or more miscarriages in their medical history, were examined immediately after the termination of pregnancy up to 12 weeks. The control group consisted of 20 healthy non-pregnant women. The content of natural killers of peripheral blood pNK - CD16+, interleukins IL2, IL6, IL10, TNFα; VEGF and γINF were examined by the method of enzyme immunoassay. In women with a history of recurrent miscarriage, immediately after the next termination of pregnancy in the first trimester examinations revealed immune shifts characterized by increased activity pNK - CD16+ compared with the control group - 27.5% (р<0,01); also an increase in the production of interleukins: TNFα to 39.0 pg/ml compared with the control group - 27.5 pg/ml (р<0,05) and IL6 up to 28.5 pg/ml in the control group 13.95 pg/ml (р<0,01). The above changes indicate a dysregulation of the immune system what may be related to the termination of pregnancy in the first trimester.