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Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
Published on: April 6, 2022
INTESTINAL MICROBIOTA IN ALZHEIMER'S DISEASE
1Sumy State University, Medical Institute, Sumy, Ukraine.
Abstract:
The study aimed to assess the qualitative and quantitative composition of the intestinal microflora in Alzheimer's disease patients. The paper presents the data obtained from a microbiological study of the intestinal microflora in Alzheimer's disease patients (n=37) aged 69±0.5 years. The analysis of the microbiological study of the feces of Alzheimer's disease patients found that the intestinal microflora of such patients had both qualitative and quantitative dysbiotic changes of various degrees of manifestation. The composition of the intestinal microflora of these patients showed a significant decrease in Bifidumbacterium spp. and Lactobacillus spp.: the lowest quantitative indicators of Lactobacillus spp. were observed in patients with a decompensated form of dysbiosis lg 4.48 CFU/g, and Bifidumbacterium spp. - in patients with a subcompensated form of dysbiosis (lg 3.7 CFU/g). Indicators of adhesive activity of Lactobacillus spp. isolates from Alzheimer's disease patients in the conditions of micro-aeration on defatted milk were higher by an average of 1.2 times (P <0.05), which can be used in the development of additional therapeutic strategies - autobiotic therapy, which has a positive effect both on the microbiocenosis and the state of patients with Alzheimer's disease.
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