Indonesian registry on atrial fibrillation (OneAF).

Area of Science:

• Cardiology
• Clinical Research
• Epidemiology

Background:

• Optimal therapeutic international normalized ratio (INR) for non-valvular and valvular atrial fibrillation (AF) in Indonesia remains undetermined.
• The Indonesian Registry on Atrial Fibrillation (OneAF) was established to address this knowledge gap.
• The study is registered at clinicaltrials.gov (NCT04222868).

Purpose of the Study:

• To determine a safe and beneficial range of INR for Indonesian patients with non-valvular and valvular AF.
• To gain insights into regional variations in anticoagulant treatment for AF.
• To understand the implementation of rhythm/rate control strategies and their impact on clinical outcomes.

Main Methods:

• Prospective, multicentre, nationwide, observational study.
• Collaboration of the Indonesian Heart Rhythm Society (InaHRS) across hospitals with cardiac electrophysiologists.
• Recruitment of non-valvular and valvular AF patients, with data collection on demographics, medical history, diagnostics, treatment, and events.

Main Results:

• 1568 respondents enrolled in the non-cohort registry.
• 67.8% of respondents have non-valvular AF, and 32.2% have valvular AF.
• The registry is expected to provide valuable data on AF management in Indonesia.

Conclusions:

• The OneAF registry is crucial for establishing evidence-based INR targets in Indonesian AF patients.
• Findings will inform regional anticoagulant treatment strategies and clinical practice guidelines.
• The study will contribute to improving the management and outcomes of cardiocerebrovascular events in AF patients.