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Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2

Amanda B Payne1, Zunera Gilani1, Shana Godfred-Cato1

  • 1COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia.

JAMA Network Open
|June 10, 2021
PubMed

Insights

Multisystem inflammatory syndrome in children (MIS-C) is rare but disproportionately affects minority children. Incidence was higher in Black, Hispanic, and Asian children compared to White children, especially those aged 5 and younger.

Area of Science:

  • Pediatric infectious diseases
  • Epidemiology
  • Public health surveillance

Background:

  • Multisystem inflammatory syndrome in children (MIS-C) is a serious condition linked to SARS-CoV-2 infection.
  • Limited data exists on the population-based incidence of MIS-C.

Purpose of the Study:

  • To estimate the incidence of MIS-C per person-months in children under 21.
  • To determine MIS-C incidence relative to SARS-CoV-2 infections in the same age group.

Main Methods:

  • Utilized enhanced surveillance data from 7 US jurisdictions (April-June 2020).
  • Calculated incidence using census data and adjusted SARS-CoV-2 case counts.
  • Analyzed data stratified by race/ethnicity and age group (≤5, 6-10, 11-15, 16-20 years).

Main Results:

  • Reported 248 MIS-C cases; median age 8 years, 53.6% male.
  • Overall MIS-C incidence was 5.1 per 1,000,000 person-months.
  • Incidence was significantly higher in Black, Hispanic/Latino, and Asian children compared to White children.
  • Incidence per SARS-CoV-2 infection was 316 per 1,000,000 infections, also higher in minority groups.
  • Youngest children (≤5 and 6-10 years) exhibited the highest incidence rates.

Conclusions:

  • MIS-C is a rare but significant complication of SARS-CoV-2 infection.
  • Disparities in MIS-C incidence exist across racial/ethnic groups.
  • Further research is needed to understand these disparities and inform targeted public health strategies.
Abstract

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