Aptamer-Targeted Photodynamic Platforms for Tumor Therapy
Jincong Yan1,2, Tian Gao2, Zhongzhong Lu2
1Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, 200444 Shanghai, China.
ACS Applied Materials & Interfaces
|June 10, 2021
Summary
Aptamer-targeted photodynamic therapy (PDT) enhances drug delivery to tumors. Aptamer-modified photosensitizers (PSs) and nanocarriers improve tumor targeting and therapeutic efficiency for better cancer treatment outcomes.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Controlled delivery of photosensitizers (PSs) to tumors is a key challenge in photodynamic therapy (PDT).
- Aptamers, short oligonucleotide sequences, offer specific molecular recognition for targeted delivery.
Purpose of the Study:
- To review recent advancements in aptamer-targeted photodynamic platforms for tumor therapy.
- To highlight the design and application of aptamer-modified PSs and nanocarriers for enhanced tumor treatment.
Main Methods:
- Selection and application of aptamers for tumor targeting.
- Development of aptamer-conjugated PSs and PSs-loaded nanocarriers.
- Exploration of synergistic therapeutic platforms and imaging-guided theranostics.
Main Results:
- Aptamer modification enables specific binding to tumor cells, improving PSs delivery.
- Aptamer-targeted PDT platforms demonstrate superior reactive oxygen species generation and therapeutic efficiency in tumors.
- Synergistic therapies and theranostics show promise for integrated cancer treatment.
Conclusions:
- Aptamer-targeted photodynamic platforms represent a significant advancement in precision oncology.
- Future research should focus on optimizing aptamer selection and developing novel synergistic and theranostic strategies.
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