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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor

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Molecular targets in GI malignancies - A pathologist's perspective.

Satyajit Pawar¹, Atul Sharma¹

¹Department of Medical Oncology, Dr. B. R. A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.

Indian Journal of Pathology & Microbiology

|June 17, 2021

Summary

Advanced gastrointestinal cancer treatment is evolving with personalized medicine. Molecular profiling identifies key targets like BRAF, RAS, Her2, and PDL1, guiding novel targeted therapies for better patient outcomes.

Keywords:

Gastrointestinal cancer molecular targets monoclonal antibodies targeted therapy tyrosine kinase inhibitors

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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

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Area of Science:

Oncology
Molecular Biology
Genetics

Background:

Advances in molecular diagnostics and cancer pathogenesis reveal new therapeutic targets.
Personalized medicine is transforming cancer treatment strategies, particularly for advanced gastrointestinal (GI) malignancies.

Purpose of the Study:

To review established and emerging molecular markers for GI malignancies.
To discuss testing methodologies and evidence supporting their clinical application.

Main Methods:

Literature review of molecular diagnostics in GI cancer.
Analysis of current therapeutic strategies based on molecular profiling.
Evaluation of novel targeted therapies and their pathways.

Main Results:

Standard molecular profiling includes BRAF/RAS for colorectal cancer and Her2/PDL1 for gastroesophageal cancers.
Tissue-agnostic markers such as microsatellite instability (MSI), tumor mutational burden (TMB), and NTRK are increasingly utilized.
Emerging targeted therapies show promise against FGFR, EGFR, PI3K-AKT, and DNA Damage Response (DDR) pathways.

Conclusions:

Molecular markers are crucial for personalized treatment of advanced GI cancers.
A comprehensive understanding of these markers and testing methods is essential for clinical practice.
Ongoing research into novel targeted therapies holds significant potential for improving patient care.