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Association between convalescent plasma and the risk of mortality among patients with COVID-19: a meta-analysis

Shinta Oktya Wardhani1, Jonny Karunia Fajar2, Laksmi Wulandari3

  • 1Division of Hematology and Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia.

F1000Research
|June 18, 2021
PubMed

Insights

Convalescent plasma (CCP) therapy may reduce mortality in COVID-19 patients. This meta-analysis found a lower mortality risk for patients receiving CCP compared to standard treatment alone.

Area of Science:

  • Infectious Diseases
  • Immunology
  • Critical Care Medicine

Background:

  • Convalescent plasma (CCP) has been explored for various infectious diseases.
  • The effectiveness of CCP for treating coronavirus disease 2019 (COVID-19) remains debated.
  • This study evaluates CCP as an add-on therapy for COVID-19 patients.

Purpose of the Study:

  • To assess the efficacy of convalescent plasma (CCP) as adjunctive treatment in COVID-19 patients.
  • To determine the impact of CCP on mortality rates in COVID-19.

Main Methods:

  • Systematic literature search across Embase, PubMed, Web of Science, Cochrane, and MedRxiv.
  • Quality assessment of included studies using modified Jadad and Newcastle-Ottawa scales.
  • Meta-analysis comparing mortality rates between patients treated with and without CCP.

Main Results:

  • Twelve studies with 1,937 patients receiving CCP and 3,405 patients not receiving CCP were analyzed.
  • Overall mortality risk was 1.92-fold higher in patients without CCP (p=0.0005).
  • In severe COVID-19 cases, mortality risk was 1.32-fold higher without CCP (p=0.0040).

Conclusions:

  • Convalescent plasma (CCP) as an adjunctive therapy may significantly reduce mortality in COVID-19 patients.
  • The findings suggest a beneficial role for CCP in managing COVID-19, particularly in severe cases.

Keywords:
COVID-19convalescent plasmamortalityoutcomespassive immunization

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