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Busting Myths in Compound Handling Practices for Assay Developers.

Rosalia Gonzales¹, Travis Mathewson¹, Jefferson Chin¹

¹Pfizer, Groton, CT, USA.

SLAS Technology

|June 21, 2021

Summary

This summary is machine-generated.

Good laboratory practices for compound sample handling are evolving. This study presents data to debunk myths and improve collaboration between screening and sample handling groups for better drug discovery outcomes.

Keywords:

HTS acoustic droplet ejection analytical and purification automated biology compound management engineering high-throughput screening robotics and instrumentation

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Area of Science:

Drug Discovery and Development
Chemical Biology
Assay Development

Background:

Modern screening collections have evolved since the early 2000s, necessitating updated best practices.
Traditional compound sample handling practices persist despite a lack of empirical data, leading to assay failures.
A disconnect often exists between plate-based screeners and compound sample handling teams, hindering troubleshooting efforts.

Purpose of the Study:

To highlight recommended practices for ensuring compound sample integrity.
To present data-driven insights for debunking common myths in sample handling.
To foster collaboration between screening and sample handling groups for improved assay performance.

Main Methods:

Review of established and emerging best practices in compound sample handling.
Presentation of experimental data to validate or refute traditional handling methods.
Analysis of inter-group communication and collaboration strategies.

Main Results:

Identification of key practices that maintain sample integrity during screening.
Empirical data presented to challenge outdated handling myths.
Demonstration of how collaborative relationships improve assay success rates.

Conclusions:

Adoption of evidence-based practices is crucial for reliable screening results.
Myth-busting data can resolve discrepancies and improve troubleshooting.
Strong collaboration between screening and sample handling is essential for efficient drug discovery.