Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An injectable hydrogen-producing bacteria hydrogel for cardiac repair in rodent and porcine models.

Nature biomedical engineering·2026
Same author

Active protein-capturing hydrogel for broad-spectrum pathogen defense.

Science advances·2026
Same author

Intrapericardially injected hydrogel loaded with stromal cell secretome microparticles improves post-infarction myocardial repair in pigs.

European heart journal·2026
Same author

Inhalable bioadhesive barrier for lung protection and clearance of fine particulate matter.

Bioactive materials·2026
Same author

Exosomes: bridge metabolic regulation in cardiac repair.

npj biomedical innovations·2026
Same author

Single intramuscular injection of self-amplifying RNA of <i>Nppa</i> to treat myocardial infarction.

Science (New York, N.Y.)·2026

Related Experiment Video

Updated: Nov 1, 2025

Cardiac Spheroids as in vitro Bioengineered Heart Tissues to Study Human Heart Pathophysiology
10:41

Cardiac Spheroids as in vitro Bioengineered Heart Tissues to Study Human Heart Pathophysiology

Published on: January 23, 2021

8.0K

Bioengineering Technologies for Cardiac Regenerative Medicine.

Mira Chingale1, Dashuai Zhu1,2, Ke Cheng1,2

  • 1Department of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC, United States.

Frontiers in Bioengineering and Biotechnology
|June 21, 2021
PubMed
Summary

Bioengineering offers innovative solutions for cardiac regenerative medicine by overcoming challenges like limited stem cells and poor therapeutic delivery. Advanced techniques enable patient-specific cell generation and targeted delivery for heart repair.

Keywords:
bioengineeringcardiac patchcardiac repaircell reprogrammingexosometargeting

More Related Videos

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential
07:41

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

7.8K
Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing
11:09

Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing

Published on: March 19, 2013

11.3K

Related Experiment Videos

Last Updated: Nov 1, 2025

Cardiac Spheroids as in vitro Bioengineered Heart Tissues to Study Human Heart Pathophysiology
10:41

Cardiac Spheroids as in vitro Bioengineered Heart Tissues to Study Human Heart Pathophysiology

Published on: January 23, 2021

8.0K
Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential
07:41

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

Published on: January 18, 2019

7.8K
Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing
11:09

Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing

Published on: March 19, 2013

11.3K

Area of Science:

  • Regenerative Medicine
  • Bioengineering
  • Cardiovascular Research

Background:

  • Cardiac regenerative medicine faces significant hurdles including a scarcity of adult cardiac stem cells, slow cardiomyocyte turnover, and challenges in delivering therapeutics to damaged heart tissue.
  • Existing limitations hinder effective heart repair and regeneration strategies.

Purpose of the Study:

  • To review recent advancements at the intersection of bioengineering and cardiac regenerative medicine.
  • To highlight innovative biotechnologies addressing key challenges in cardiac repair.

Main Methods:

  • Exploration of cell reprogramming technologies (direct and indirect) for generating patient-specific cardiomyocytes.
  • Utilization of viral and non-viral vectors for gene editing in cardiac remodeling.
  • Application of cell-derived factors (exosomes, miRNAs) and engineered particles for enhanced therapeutic delivery.
  • Implementation of protein modification and membrane coating for targeted drug delivery.
  • Development of cardiac patches and 3D printing/culture techniques for tissue engineering.

Main Results:

  • Bioengineering approaches provide novel solutions for patient-specific cardiomyocyte generation.
  • Engineered particles and targeted delivery systems overcome limitations of traditional cell therapies.
  • Advanced fabrication methods like 3D printing enable the creation of functional cardiac tissues.

Conclusions:

  • Bioengineering and biotechnologies are revolutionizing cardiac regenerative medicine.
  • These innovations offer promising strategies for overcoming current therapeutic challenges and improving outcomes for heart repair.