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Visualizing Protein Kinase A Activity In Head-fixed Behaving Mice Using In Vivo Two-photon Fluorescence Lifetime Imaging Microscopy
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Highly selective two-photon fluorescent off-on probes for imaging tyrosinase activity in living cells and tissues
Yixin Cui1, Sang Jun Park2, Xiaofeng Wu1
1Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 120-750, Korea. jyoon@ewha.ac.kr.
Abstract:
A coumarin-based two-photon (TP) fluorescent off-on probe has been developed for detecting tyrosinase activity. High selectivity, sensitivity and biocompatibility enable the probes to successfully image tyrosinase activity in live cells and tissues using TP microscopy.

